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- W2388447403 abstract "Objective To investigate the minocycline influences on expression of VEGF,IL-1β and TNF-α for in vascular dementia brain and serum level of VEGF,IL-1β and TNF-α in vascular dementia rats,to study neuroprotection mechanism of minocycline for vascular dementia.Methods Wistar rats were randomly divided into: normal group(N),sham group(S),vascular dementia model group(M) and minocycline treatment group(MT).Serum level,expression of VEGF,IL-1β and TNF-α were measured by enzyme linked immunosorbent assay.Results The serum level,expression of IL-1β and TNF-α in MT groups were lower than that of in M(P0.05),the serum level and expression of VEGF in MT groups were higher than that of in M(P0.05);the serum level and expression of VEGF,IL-1β and TNF-α in MT and M groups were higher than that of in N,S(P0.01).Conclusion Minocycline can restrain the expression of IL-1β,TNF-α and increase the expression of VEGF in vascular dementia.minocycline can enhance recovery of cerebral vascular to protect neural function by restraining neuroinflammation." @default.
- W2388447403 created "2016-06-24" @default.
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- W2388447403 date "2008-01-01" @default.
- W2388447403 modified "2023-09-22" @default.
- W2388447403 title "Upregulation of VEGF and downregulation of IL-1β,TNF-α in vascular dementia rats by minocycline" @default.
- W2388447403 hasPublicationYear "2008" @default.
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