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- W2388497142 abstract "Objective To investigate the effects of montelukast Na on serum eosinophil counting and cysteiny LTs(CysLTs)in infants with respiratory syncytial virus(RSV)bronchiolitis and the therapeutic effects.Methods 60 infants with RSV bronchiolitis aged 6-18 months were randomly divided into two groups:the montelukast treated group(30 cases)and routine treated group(30 cases).The patient in routine treated group were treated by routine complex treatment;on the basis of routine complex treatment,the patient in montelukast treated group were used montelukast Na,taking 2.5 mg once daily orally montelukast Na,with a treatment course of 7 days.20 health infants were served as normal control group.Before starting treatment and 7 days later,clinical effects were observed;concentration of serum CysLTs was measured;also blood esoinophil was counted.Results Before treatment,the level of CysLTs and eosinophil counting in patients with RSV bronchiolitis was significantly higher than that in normal control group(P0.01).After treatment,the time that patients’ symptoms and signs returned to normal state was obviously earlier in montelukast treated group than that in routine treated group(P0.01);eosinophil counting and CysLTs level decreased significantly in montelukast treated group compared with that in routine treated group(P0.05);there were no significantly difference in eosinophil counting and CysLTs level both montelukast treated group and normal control group(P0.05);eosinophil counting and CysLTs level was higher significantly in routine treated group compared with that in normal control group(P0.05).Conclusion Montelukast Na can lower the level of CysLTs and eosinophil counting in serum of RSV bronchiolitis patients,which plays an important role for antagonizing airway inflammation of RSV bronchiolitis,meanwhile it can reduce course of the illness and possess the obviously promoter action to disease recovery,too." @default.
- W2388497142 created "2016-06-24" @default.
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- W2388497142 date "2008-01-01" @default.
- W2388497142 modified "2023-09-28" @default.
- W2388497142 title "Effects of montelukast Na on blood eosinophil and cysteiny LTs in infants with respiratory syncytial virus bronchiolitis" @default.
- W2388497142 hasPublicationYear "2008" @default.
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