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- W2388498745 abstract "Objective: To study the anti-inflammatory effect of scoparone(Sco) on asthma and its mechanism in guinea pigs.Methods: Guinea pig model of late asthmatic reaction(LAR) was established.The content of interleukin-5(IL-5) in serum and bronchial alveolar lavage fluid(BALF) was detected by using immunohistochemical method.The content of phospholipase A_(2)(PLA_(2)) in the lysosomes of pulmonary tissues was detected by image analysis after staining.Results: The contents of IL-5 in serum and BALF and PLA_(2)in the lysosomes of pulmonary tissues in the asthma group were significantly higher than those in the control group(P0.05).The contents of IL-5 and PLA_(2)in the treatment group(Sco of 42 and 340 mg/L) were significantly lower than those in the asthma group(P0.05).Conclusion: Sco can inhibit inflammation by lowering the contents of IL-5 in serum and BALF and PLA_(2)in pulmonary tissues in asthmatic guinea pig model." @default.
- W2388498745 created "2016-06-24" @default.
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- W2388498745 date "2006-01-01" @default.
- W2388498745 modified "2023-09-28" @default.
- W2388498745 title "Inhibitory effect of scoparone on inflammatory mediator in asthmatic guinea pig model" @default.
- W2388498745 hasPublicationYear "2006" @default.
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