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- W2388511794 abstract "A RP-HPLC method was used for the determination of eprinomectin concentrations in sheep plasma following i.v. and s.c. administration at a single dose of 0.2 mg/kg. The extract of plasma samples were loaded onto a C_(18) catridge. After solvent exchange,the methanol eluate was derivatized via the addition of 1-methylimidazole and trifluoroacetic anhydride in acetonitrile.Then the fluorescent derivative was analyzed by using fluorescene detector. Eprinomectin in plasma within 2.5~200 ng/mL ranges had a good linear relationship (R=0.996 8) .The average recovery of the method was 99.65%±3.84%.The RSDs of within-day and between-day assays were less than 10%,12% respectively. Drug concentration-time data in plasma were founded to be fitted to a two-compartment open model and one-compartment open model after i.v.and s.c. administration respectively.The main pharmacokinetic parameters demonstrated that eprinomectin was distributed widely and eliminated slowly after i.v. adminstration, After s.c. adminstration it was Absorbed completely and had longer residue time in sheep ,eliminated slower than that of (i.v.) adminstration." @default.
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- W2388511794 date "2005-01-01" @default.
- W2388511794 modified "2023-09-25" @default.
- W2388511794 title "Study on Pharmacokinetics of Eprinomectin in Sheep Following Intravenous and Subcutaneous Administration" @default.
- W2388511794 hasPublicationYear "2005" @default.
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