Matches in SemOpenAlex for { <https://semopenalex.org/work/W2388542532> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2388542532 abstract "Objective To explore the toxic effects of iron on nigral dopaminergic(DA) neurons and provide the data for elucidating the pathogenesis of Parkinson's disease. Methods Iron was stereotaxically infused into right substantia nigra(SN). Tyrosine hydroxylase(TH)-positive cells in the substantia nigra were examined by immunohistochemical assay and the contents of DA and its metabolites in the striatum were measured by high performance liquid chromatography with electrochemical detection (HPLC-ECD) 6 weeks later. Free radical metabolism in the midbrain was also examined by chemical spectrophotometry. Results Infusions of high dose iron(40 μg) induced significant degeneration and loss of TH positive cells in the pars compacta of SN, marked reduction of striatal DA and its metabolites, and elevated lipid peroxidative products and decreased glutathione. Infusion of low dose iron(4 μg) also induced lipid peroxidation, but did not produce significant loss of TH positive cells in the pars compacta of SN. Conclusions Excess iron could induce the degeneration of nigral DA neurons; iron-mediated freeradical synthesis might play an important role in the pathogenesis of Parkinson's disease." @default.
- W2388542532 created "2016-06-24" @default.
- W2388542532 creator A5076344368 @default.
- W2388542532 date "2002-01-01" @default.
- W2388542532 modified "2023-09-24" @default.
- W2388542532 title "Iron induces the degeneration of nigral dopaminergic neurons in rats" @default.
- W2388542532 hasPublicationYear "2002" @default.
- W2388542532 type Work @default.
- W2388542532 sameAs 2388542532 @default.
- W2388542532 citedByCount "0" @default.
- W2388542532 crossrefType "journal-article" @default.
- W2388542532 hasAuthorship W2388542532A5076344368 @default.
- W2388542532 hasConcept C126322002 @default.
- W2388542532 hasConcept C134018914 @default.
- W2388542532 hasConcept C137183658 @default.
- W2388542532 hasConcept C159167319 @default.
- W2388542532 hasConcept C185592680 @default.
- W2388542532 hasConcept C2776151105 @default.
- W2388542532 hasConcept C2776773494 @default.
- W2388542532 hasConcept C2779134260 @default.
- W2388542532 hasConcept C2779734285 @default.
- W2388542532 hasConcept C2780062018 @default.
- W2388542532 hasConcept C2780829032 @default.
- W2388542532 hasConcept C2780938664 @default.
- W2388542532 hasConcept C2780942790 @default.
- W2388542532 hasConcept C513476851 @default.
- W2388542532 hasConcept C55493867 @default.
- W2388542532 hasConcept C71924100 @default.
- W2388542532 hasConcept C86803240 @default.
- W2388542532 hasConceptScore W2388542532C126322002 @default.
- W2388542532 hasConceptScore W2388542532C134018914 @default.
- W2388542532 hasConceptScore W2388542532C137183658 @default.
- W2388542532 hasConceptScore W2388542532C159167319 @default.
- W2388542532 hasConceptScore W2388542532C185592680 @default.
- W2388542532 hasConceptScore W2388542532C2776151105 @default.
- W2388542532 hasConceptScore W2388542532C2776773494 @default.
- W2388542532 hasConceptScore W2388542532C2779134260 @default.
- W2388542532 hasConceptScore W2388542532C2779734285 @default.
- W2388542532 hasConceptScore W2388542532C2780062018 @default.
- W2388542532 hasConceptScore W2388542532C2780829032 @default.
- W2388542532 hasConceptScore W2388542532C2780938664 @default.
- W2388542532 hasConceptScore W2388542532C2780942790 @default.
- W2388542532 hasConceptScore W2388542532C513476851 @default.
- W2388542532 hasConceptScore W2388542532C55493867 @default.
- W2388542532 hasConceptScore W2388542532C71924100 @default.
- W2388542532 hasConceptScore W2388542532C86803240 @default.
- W2388542532 hasLocation W23885425321 @default.
- W2388542532 hasOpenAccess W2388542532 @default.
- W2388542532 hasPrimaryLocation W23885425321 @default.
- W2388542532 hasRelatedWork W151775177 @default.
- W2388542532 hasRelatedWork W1967307545 @default.
- W2388542532 hasRelatedWork W1986721841 @default.
- W2388542532 hasRelatedWork W1986740107 @default.
- W2388542532 hasRelatedWork W1988426190 @default.
- W2388542532 hasRelatedWork W1988853676 @default.
- W2388542532 hasRelatedWork W1989132357 @default.
- W2388542532 hasRelatedWork W2027648752 @default.
- W2388542532 hasRelatedWork W2049800884 @default.
- W2388542532 hasRelatedWork W2079536916 @default.
- W2388542532 hasRelatedWork W2092492531 @default.
- W2388542532 hasRelatedWork W2132659147 @default.
- W2388542532 hasRelatedWork W2351590960 @default.
- W2388542532 hasRelatedWork W2352753257 @default.
- W2388542532 hasRelatedWork W2352791485 @default.
- W2388542532 hasRelatedWork W2375768659 @default.
- W2388542532 hasRelatedWork W2380921029 @default.
- W2388542532 hasRelatedWork W2383735631 @default.
- W2388542532 hasRelatedWork W595994722 @default.
- W2388542532 hasRelatedWork W3032396341 @default.
- W2388542532 isParatext "false" @default.
- W2388542532 isRetracted "false" @default.
- W2388542532 magId "2388542532" @default.
- W2388542532 workType "article" @default.