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- W2388560306 abstract "Objective To investigate whether the expression of matrix metalloproteinases-2 and tissue inhibitors of metalloproteinases-2 was consistent with the proposed roles of these proteins in promoting invasion and metastasis in colorectal cancer.Methods Immunohistochemistry was performed to investigate the expression of MMP-2 and TIMP-2 proteins in colorectal cancer tissues from 117 consecutive patients undergoing curative resection for colorectal carcinoma(CRC)and 15 normal colon tissues.The immunostaining results and related clinicopathologic materials were analyzed with statistical methods.Kaplan-Meier method was used to calculate survival curves,and Log-rank test was performed to compare differences in survival rates of the patients with positive CRC staining and negative MMP-2,TIMP-2.Results(1)MMP-2 positive expression was found in 2 of 15 normal colon tissues,TIMP-2 positive expression was found in 8 of 15 normal colon tissues.TIMP-2 positive expressions were significantly higher than MMP-2 positive expressions in normal colon tissues(P0.05).(2)MMP-2 positive expressions were found in 74 of 117 CRC.MMP-2 positive expressions were significantly higher in CRC than in normal colon tissues(P0.05).Depth of invasion,tumor differentiation,lymphatic invasion,hepatic metastasis and TNM stage were observed more frequently in MMP-2 positive expression than in MMP-2 negative expression(P0.05).Kaplan-Meier curves showed that MMP-2 positive expression was associated with a shorter overall survival(P0.05).TIMP-2 positive expressions were found in 54 of 117 CRC.TIMP-2 negative expressions were found in 63 of 117 CRC.Lymphatic invasion,hepatic metastasis and TNM stage were observed more frequently in TIMP-2 negative expression than in TIMP-2 positive expression(P0.05).(3)Kaplan-Meier curves showed that MMP-2 positive expression was associated with a shorter overall survival(P0.05).TIMP-2 positive expression was associated with a longer overall survival(P0.05).Conclusions The balance between MMP-2 and TIMP-2 plays crucial roles in the invasion and metastasis of colorectal cancer." @default.
- W2388560306 created "2016-06-24" @default.
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- W2388560306 date "2012-01-01" @default.
- W2388560306 modified "2023-09-23" @default.
- W2388560306 title "Clinicopathologic significance of matrix metalloproteinases-2 and tissue inhibitors of metalloproteinases-2 in invasion and metastasis of colorectal cancer" @default.
- W2388560306 hasPublicationYear "2012" @default.
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