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- W2388575038 abstract "Objective To study and optimize the preparation process of porous rifampicin-loaded PLGA microspheres. Methods Porous microparticles were prepared by double emulsion solvent-extraction method. The morphology of the microspheres was examined by scanning electron microscope and the encapsulation efficiency was determined by high performance liquid chromatography. Through single factor selecting experiment,the major factors affecting the morphology and encapsulation efficiency of microspheres were investigated and optimized. Results The particle size,porous structure and encapsulation efficiency of the microspheres were influenced by the PLGA type,PLGA concentration,porogenic agent concentration,homogeneous velocity and PVA concentration. Microspheres prepared by optimized process had an average particle diameter of 8. 6 μm,and density of 0. 1g·cm- 3,which could be easily inhaled. Conclusion Low density porous microspheres with good inhalation characteristics and higher pulmonary deposition could be a new drug delivery carrier for anti-tuberculosis drugs." @default.
- W2388575038 created "2016-06-24" @default.
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- W2388575038 date "2015-01-01" @default.
- W2388575038 modified "2023-09-25" @default.
- W2388575038 title "Preparation of porous rifampicin-loaded PLGA microspheres" @default.
- W2388575038 hasPublicationYear "2015" @default.
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