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- W2388580044 abstract "Objective To test the hypothesis that protects of target organs injury in essential hypertension by losartan and telmesartan may be mediated by beyond BP lowering effect in relevant to the role of MCP-1 and CCR2 expressed in target orgens and peripheral moncytes.Methods Twenty four SHR were randomly to receive placebo low dose losartan [5 mg/(kg·d),n=6,LL],high dose losartan [30 mg/(kg·d),n=6,HL] telmisartan [30 mg/(kg·d),n=6,T] for 4 weeks.Untreated SHR(n=6) and WKY(n=6) served as controls.The expression of MCP-1 and CCR-2 in heart was examined by chemotasis assay and the concentration of serum MCP-1 protein by ELSA.Results Both HL and T decreased BP,LVM/BW,Intimal medial thickness(IMT) of thoracic aorta,and peripheral vascular fibrosis fraction(PVFR),as well as the expression of MCP-1 and CCR-2 in tissues and PVFR,as well as the expression of MCP-1 and CCR-2 in tissues and peripheral monocytes.Although LL had little effect on BP(before treatment:176.7±15.3 mm Hg vs after:174.2±17.1 mm Hg,P0.05),an analogous inhibiting impact on LVH,IMT,PVFR,the expression of MCP-1 CCR-2 in tissues and pheripheral moncytes and the chemotaxis ability of peripheral monocytes was obviously manifested.Conclusion Compared with WKY rat,the expression of MCP-1/CCR-2 in target organs in SHR was significantly increased.ARBs may protect hypertensive infury in target organs and inhibit the expression of MCP-1/CCR-2 and chemotaxis ability of monocytes by beyond BP Lowering effect." @default.
- W2388580044 created "2016-06-24" @default.
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- W2388580044 date "2007-01-01" @default.
- W2388580044 modified "2023-09-24" @default.
- W2388580044 title "Losartan and Telmisartan Inhibit the Expression of MCP-1(CCR2) in Target Organs in SHR" @default.
- W2388580044 hasPublicationYear "2007" @default.
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