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- W2388584388 abstract "Objective To evaluate the role of the expression of CD226 in PIH, and to investigate the correlation between the expression of CD226 and PDGF in PIH.Methods The expression?regulation and adhesion of CD226 on vascular endothelial cells incubated by sera from 10 PIH patients and 10 normal pregnant women repectively was detected by flow cytometry. The PDGF in the conditioned medium of two groups was detected by ELISA. Results (1) The positive rate of CD226 in PIH group is significantly higher than that in normal pregnant woman group(P0.001). After the incubation with platelets, the positive rate of CD226 in PIH group is lower than before(p0.05). (2) The PDGF expression in PIH group is much higher than that in normal pregnant woman group and is dependent on the time of stimulation(P0.001). After the incubation with platelets, a significant increase in the release of PDGF-B is observed(P0.005).Conclusion (1)There are some abnormal factors in PIH patients , which activate vascular endothelial cells. (2)CD226 plays an important role in the adhesion of platelets to vascular endothelial cells. (3)Both PDGF and CD226 are closely related to the progress of PIH, and take part in the pathophysiologic consequences of PIH." @default.
- W2388584388 created "2016-06-24" @default.
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- W2388584388 date "2005-01-01" @default.
- W2388584388 modified "2023-09-23" @default.
- W2388584388 title "The study of CD226 and PDGF in PIH serum treated endothelial cell" @default.
- W2388584388 hasPublicationYear "2005" @default.
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