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- W2388584843 abstract "OBJECTIVE To construct a population pharmacokinetic model for cyclosporine, which was constructed by NONMEM, and to adjust administration individually.METHODS Based on the population pharmacokinetic model, least square method was employed to estimate patient inter-individual variability, with one or two blood samplings. Then it was feasible to predict the concentration and its range according to dose, personal information, inter-individual variability and intra-individual variability.RESULTS ρ_0 (predosing concentration) was used to estimate the inter-individual variability and then predicted blood concentrations. The observed concentrations were matched well by ρ_0 prediction and were better than those calculated by ρ_2 (concentration at 2 h after dosing) and the union of ρ_0 and ρ_2. CONCLUSION It is feasible to perform individual administration with only one concentration using EXCEL, based on the results of population pharmacokinetics." @default.
- W2388584843 created "2016-06-24" @default.
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- W2388584843 date "2006-01-01" @default.
- W2388584843 modified "2023-09-25" @default.
- W2388584843 title "Population Pharmacokinetic Study of Cyclosporine and Its Application" @default.
- W2388584843 hasPublicationYear "2006" @default.
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