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- W2388585881 abstract "Objective To optimize the formulation of nitrendipine extended-release tablets.Methods Nitrendipine extended-release tablets were prepared by the mixture of hydroxypropyl methylcellulose(HPMC) K4M and HPMC 100LV as the basic matrix materials.Box-Behnken design-response surface method was applied to optimize the formulation of the nitrendipine extended-release tablets.Results The optimal formulation and technology were as follows: HPMC as the matrix material,lactose as the filler,sodium stearyl fumarate as the lubricant,and 85% ethanol as adhensive material and the accumulative release percentages at 1,2,4,6 and 10 h were consistent with the criterion.Conclusion Box-Behnken design-response surface method is suitable for optimizing the formulation of nitrendipine gel matrix extended-release tablets,complying with requirements of the ChP." @default.
- W2388585881 created "2016-06-24" @default.
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- W2388585881 date "2013-01-01" @default.
- W2388585881 modified "2023-09-25" @default.
- W2388585881 title "Formulation optimization of nitrendipine gel matrix extended-release tablets by Box-behnken response surface method" @default.
- W2388585881 hasPublicationYear "2013" @default.
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