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- W2388593670 abstract "Objective To investigate the effect of vascular endothelial growth factor(VEGF) on the pneum-fluid metabolism of pulmonary contusion(PC).Methods Thirty rabbits were randomly and equally divided into five groups of A1(2h after PC),A2(4h after PC),A3(6h after PC),A4(8h after PC) and C(normal control).Free fall hitting was used to establish the rats PC model.The expressions of VEGF protein and VEGF mRNA were detected by immunohistochemistry and RT-PCR,respectively.The changes of parameter of pneum-fluid metabolism were measured by weighting method.Results Compared with group C,parameters of pneum-fluid metabolism were significantly increased in groups of A1,A2,A3 and A4(P0.01).The expressions of VEGF protein and VEGF mRNA in groups of A1,A3 and A4 were higher than those in group C,which peaked at 6-8h after PC(P0.01).The expression of VEGF mRNA was negatively correlated with partial pressure of oxygen(r=-0.79,P0.01).Conclusion After PC,hypoxia and other factors promote the progression of pulmonary edema via up-regulating the expression of VEGF." @default.
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- W2388593670 date "2011-01-01" @default.
- W2388593670 modified "2023-09-27" @default.
- W2388593670 title "Effect of vascular endothelial growth factor on the pneum-fluid metabolism in early pulmonary contusion in rabbits" @default.
- W2388593670 hasPublicationYear "2011" @default.
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