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- W2388617326 abstract "Objective To evaluate the effectiveness and safety of somatostatin and the analogue-octreotide in preventing post-ERCP pancreatitis. Methods We searched Cochrane Clinical Trial Register (Issue 1, April, 2004), MEDLINE (1966-April, 2004), EMBASE (1985-April, 2004), CBM disc (1970-April, 2004) and The Clinical Trial Register of Chinese Evidence-Based Medicine Center and handsearched the related journals to identify Randomized Controlled Trials (RCT) of somatostatin and octreotide in post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP) prevention. Systematic review was conducted using the method recommended by The Cochrane Collaboration. Results Thirty-one trials involving 4 728 patients undergoing ERCP were included. Meta-analysis showed that the incidence of post-ERCP pancreatitis [OR 0.33, 95%CI 0.20 to 0.54; P= 0.000 01; NNT=13] was significantly reduced by somatostatin. Octreotide could only reduce the incidence of hyperamylasemia [OR 0.54, 95%CI 0.38 to 0.77; P= 0.000 7]. The incidence of PEP, severe PEP and post-ERCP abdominal pain could not be reduced by octreotide. Conclusions Somatostatin can prevent post-ERCP pancreatitis. Four trials are of high quality in the 12 included studies and the results are consistent with the sensitive-analysis, so it is credible to some extent.However, existing evidence does not support that octreotide can reduce the incidence of PEP, so it is not recommended for this indication. Sensitive-analysis even showed that octreotide could increase the incidence of PEP. Therefore, whether it is necessary to carry out further clinical trials should be considered with caution." @default.
- W2388617326 created "2016-06-24" @default.
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- W2388617326 date "2005-01-01" @default.
- W2388617326 modified "2023-09-23" @default.
- W2388617326 title "Somatostatin and Octreotide in Preventing Post-ERCP Pancreatitis: A Systematic Review" @default.
- W2388617326 hasPublicationYear "2005" @default.
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