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- W2388626421 abstract "To study the effect of antisense focal adhesion kinase (FAK) oligodeoxynucleotide on the biological behaviors of U251 MG cells. Methods LipofecTAMINE-mediated antisense FAK ODN was transfected into U251 MG cells. Western blot analysis was used to detect the expression of FAK. The biological behaviors of human glioma cells were investigated. Results FAK anti-sense ODNs were transfected efficiently by cationic lipid (85.9%). FAK were inhibited significantly after FAK antisense ODNs transfection. For U251 MG cells, antisense FAK ODNs significantly inhibited the proliferation by 64.52% and reduced the invasion cell number to 21.7. The cells at S phase were decreased to 25.16 % and the occurrence of apoptosis increased significantly to 34.5 % in the group treated with antisense FAK ODNs. Apoptosis cells were observed by transmission electron microscopy. Conclusion Antisense FAK ODNs can decrease the FAK expression significantly, resulting the reduced ability of U251 MG cells to invade. FAK suppression significantly inhibits the proliferation of U251MG cells and induces their apoptosis." @default.
- W2388626421 created "2016-06-24" @default.
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- W2388626421 date "2006-01-01" @default.
- W2388626421 modified "2023-09-25" @default.
- W2388626421 title "Influence of focal adhesion kinase on the biological behaviors of human glioma cells" @default.
- W2388626421 hasPublicationYear "2006" @default.
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