Matches in SemOpenAlex for { <https://semopenalex.org/work/W2388632237> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2388632237 abstract "Objective To investigate the resistance of rosiglitazone(RSG) to cardiomyocyte hypertrophy induced by high glucose and insulin(HGI) as well as the relevant mechanism.Methods The cardiomyocytes of suckling SD rats were cultured under HGI condition to establish cardiomyocyte hypertrophy model.The model rats were treated with RSG at various concentrations.The effect of RSG on HGI-induced cardiomyocyte hypertrophy was observed using the cell surface area,total protein content and atrial natriuretic peptide(ANP) mRNA level as indicators.The expression of peroxisome proliferator-activated receptor-γ(PPAR-γ) and endothelial nitric oxide synthase(eNOS) at mRNA level were determined by real-time PCR,while those at protein level by Western blot.The eNOS and nitric oxide(NO) contents were determined by double antibody sandwich ABC-ELISA and nitrate reduction method respectively.Results HGI induced cardiomyocyte hypertrophy in rats successfully.RSG showed dose-dependent inhibitory effect on HGI-induced cardiomyocyte hypertrophy,up-regulated HGI-induced decrease of PPAR-γ and eNOS mRNA levels,and increased the expression level of PPAR-γ protein as well as eNOS and NO contents(each P 0.05).However,both the PPAR-γ inhibitor GW9662 and NOS inhibitor L-NAME blocked the above-mentioned effects of RSG.Conclusion RSG resisted HGI-induced cardiomyocyte hypertrophy by activating PPAR-γ,increasing eNOS content and promoting NO release." @default.
- W2388632237 created "2016-06-24" @default.
- W2388632237 creator A5051180205 @default.
- W2388632237 date "2012-01-01" @default.
- W2388632237 modified "2023-09-23" @default.
- W2388632237 title "Resistance of rosiglitazone to cardiomyocyte hypertrophy induced by high glucose and insulin and relevant mechanism" @default.
- W2388632237 hasPublicationYear "2012" @default.
- W2388632237 type Work @default.
- W2388632237 sameAs 2388632237 @default.
- W2388632237 citedByCount "0" @default.
- W2388632237 crossrefType "journal-article" @default.
- W2388632237 hasAuthorship W2388632237A5051180205 @default.
- W2388632237 hasConcept C104317684 @default.
- W2388632237 hasConcept C105580179 @default.
- W2388632237 hasConcept C126322002 @default.
- W2388632237 hasConcept C134018914 @default.
- W2388632237 hasConcept C167414201 @default.
- W2388632237 hasConcept C170493617 @default.
- W2388632237 hasConcept C185592680 @default.
- W2388632237 hasConcept C187345961 @default.
- W2388632237 hasConcept C2775915353 @default.
- W2388632237 hasConcept C2776415932 @default.
- W2388632237 hasConcept C2777391703 @default.
- W2388632237 hasConcept C2777622882 @default.
- W2388632237 hasConcept C2778069365 @default.
- W2388632237 hasConcept C2778198053 @default.
- W2388632237 hasConcept C2778326061 @default.
- W2388632237 hasConcept C2779306644 @default.
- W2388632237 hasConcept C2780152017 @default.
- W2388632237 hasConcept C519581460 @default.
- W2388632237 hasConcept C55493867 @default.
- W2388632237 hasConcept C71924100 @default.
- W2388632237 hasConcept C86803240 @default.
- W2388632237 hasConceptScore W2388632237C104317684 @default.
- W2388632237 hasConceptScore W2388632237C105580179 @default.
- W2388632237 hasConceptScore W2388632237C126322002 @default.
- W2388632237 hasConceptScore W2388632237C134018914 @default.
- W2388632237 hasConceptScore W2388632237C167414201 @default.
- W2388632237 hasConceptScore W2388632237C170493617 @default.
- W2388632237 hasConceptScore W2388632237C185592680 @default.
- W2388632237 hasConceptScore W2388632237C187345961 @default.
- W2388632237 hasConceptScore W2388632237C2775915353 @default.
- W2388632237 hasConceptScore W2388632237C2776415932 @default.
- W2388632237 hasConceptScore W2388632237C2777391703 @default.
- W2388632237 hasConceptScore W2388632237C2777622882 @default.
- W2388632237 hasConceptScore W2388632237C2778069365 @default.
- W2388632237 hasConceptScore W2388632237C2778198053 @default.
- W2388632237 hasConceptScore W2388632237C2778326061 @default.
- W2388632237 hasConceptScore W2388632237C2779306644 @default.
- W2388632237 hasConceptScore W2388632237C2780152017 @default.
- W2388632237 hasConceptScore W2388632237C519581460 @default.
- W2388632237 hasConceptScore W2388632237C55493867 @default.
- W2388632237 hasConceptScore W2388632237C71924100 @default.
- W2388632237 hasConceptScore W2388632237C86803240 @default.
- W2388632237 hasLocation W23886322371 @default.
- W2388632237 hasOpenAccess W2388632237 @default.
- W2388632237 hasPrimaryLocation W23886322371 @default.
- W2388632237 hasRelatedWork W1966375230 @default.
- W2388632237 hasRelatedWork W1988591831 @default.
- W2388632237 hasRelatedWork W1993982913 @default.
- W2388632237 hasRelatedWork W2025882888 @default.
- W2388632237 hasRelatedWork W2090742340 @default.
- W2388632237 hasRelatedWork W2218475106 @default.
- W2388632237 hasRelatedWork W2232351085 @default.
- W2388632237 hasRelatedWork W2271491473 @default.
- W2388632237 hasRelatedWork W2350534538 @default.
- W2388632237 hasRelatedWork W2351404821 @default.
- W2388632237 hasRelatedWork W2352952570 @default.
- W2388632237 hasRelatedWork W2356590925 @default.
- W2388632237 hasRelatedWork W2366467018 @default.
- W2388632237 hasRelatedWork W2371587952 @default.
- W2388632237 hasRelatedWork W2376834543 @default.
- W2388632237 hasRelatedWork W2381287440 @default.
- W2388632237 hasRelatedWork W2393199226 @default.
- W2388632237 hasRelatedWork W2753824651 @default.
- W2388632237 hasRelatedWork W2901872460 @default.
- W2388632237 hasRelatedWork W3186943967 @default.
- W2388632237 isParatext "false" @default.
- W2388632237 isRetracted "false" @default.
- W2388632237 magId "2388632237" @default.
- W2388632237 workType "article" @default.