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- W2388639038 abstract "The trihydrate of monosodium alendronate(MK _ 0217) is an important bisphosphonate drug for treatment of a variety of bone diseases. As a highly polar and thermally labile compound, alendronate is not amenable to electron impact mass spectrometry. Electrospray(ES)MS both in positive and in negative ionization mode was used to analyze it. The results showed that its sensitivity was higher in positive ionization mode than in negative one. The in _ source collision induced dissociation fragmentation pathways of alendronate are similar in both positive and negative ionization mode, which are mainly elimination of phosphorous acid and dehydration reaction. Strong peaks of + and cluster ions of + and + in positive ionization mode were readily observed. It is helpful to determine molecular weight of similar compounds. Therefore, ES-MS is a useful method for analysis of such highly polar and thermally labile compounds." @default.
- W2388639038 created "2016-06-24" @default.
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- W2388639038 date "2002-01-01" @default.
- W2388639038 modified "2023-09-25" @default.
- W2388639038 title "ESI-MS of Drug for Bone Disease Alendronate" @default.
- W2388639038 hasPublicationYear "2002" @default.
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