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- W2388682690 abstract "AIM: To study the antiviral effects of the complex of H ypericum perforatum L and lysine hydrochloride against herpes simplex v irus type 1 and varicella-zoster virus (VZV), and to evaluate the LD 50 of the complex in mice. METHODS: The cytotoxities to Vero cells an d 2BS cells and the antiviral activities were evaluated by cytopathic effect (CP E) inhibition assay. ICR mice were administrated(ig)the complex (21) to dete rmine LD 50 . RESULTS: The complex significantly inhibited t he CPE of HSV-1 and VZV. MIC ranged from 9.7 to 19.5 mg·L -1 , IC 50 ranged from 6.8 to 9.7 mg·L -1 . LD 50 of the complex with ratio 21 was 11.7 g·kg -1 with 95% confidence inter val of 6.5 - 17.2 g·kg -1 in ICR mice. CONCLUSION: The complex of Hypericum perforatum L and lysine hydrochlor ide has good effects on inhibiting HSV-I and VZV in vitro. The complex (21) is safe in mice." @default.
- W2388682690 created "2016-06-24" @default.
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- W2388682690 date "2004-01-01" @default.
- W2388682690 modified "2023-09-28" @default.
- W2388682690 title "Antiviral activity of complex of Hypericum perforatum Lextract and lysine hydrochloride on herpes virus" @default.
- W2388682690 hasPublicationYear "2004" @default.
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