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- W2388687145 abstract "Objective To validate the clinical value of the MSKCC nomogram that predicts the presence of sentinel lymph node(SLN) metastasis in Chinese early-stage breast cancer population. Methods Data were collected from 524 patients with successful SLN biopsy who were treated during 2005 March to 2009 October. Touch imprint cytology(TIC) and serial section with HE staining were performed routinely on each sentinel node. MSKCC nomogram was used to estimate probability of SLN involvement and compared with actual probability after grouping into deciles. A ROC curve was drawn and predictive accuracy was assessed by calculating the area under the receiver-operating characteristic(ROC) curve. Results It was shown that age,tumor size,histological grade and lymphovascular invasion was correlated with the probability of SLN metastasis by univariate analysis. By Multivariate analysis,tumor size and lymphovascular invasion were identified as independent predictors of SLN metastasis. The odds ratio(OR) of the lymphovascular invasion was 9.462(95% CI 5.551-16.130) while OR of tumor size was 1.429(95% CI 1.142-1.788) . The trend of actual probability in various decile groups was comparable to the predicted probability. The area under the ROC curve was 0.757 as compared to 0.754 in the original population. Conclusion The MSKCC nomogram that predicts metastasis of breast cancer in the sentinel lymph node performed good in a Chinese breast cancer population. It could provide a clinical accessory in the preoperative discussion of the patients." @default.
- W2388687145 created "2016-06-24" @default.
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- W2388687145 date "2011-01-01" @default.
- W2388687145 modified "2023-09-24" @default.
- W2388687145 title "Validation of MSKCC nomogram in predicting sentinel lymph node metastasis of breast cancer" @default.
- W2388687145 hasPublicationYear "2011" @default.
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