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- W2388687492 abstract "Objective To study on free hepatitis b virus(HBV) DNA in blood serum of hepatitis b patients.Methods Total HBV DNA was detected in blood serum treated with DNA extracting solution.Free HBV DNA was detected in blood serum treated with distilled water.HBV DNA was measured by real-time fluorescence quantitative PCR.ALT and AST were measured by automatic biochemistry analyzer.Results Free HBV DNA was detected in 27 out of 30 cases.The positive rate was 70.0 percent.There was Free HBV DNA detected in blood serum which total HBV DNA load was above or equal to 1.0×105 copies/ml.The average of total HBV DNA load was(1.6±3.1)×108 copies/ml.The average of free HBV DNA load was(4.8±8.2)×106 copies/ml.The free HBV DNA load was positive correlation with the total HBV DNA load(r=0.545,P0.05).The liver function was normal in 20 out of 30 cases.And the liver function was not normal in 10 out of 30 cases.Free HBV DNA was detected in 14 cases of normal liver function group.The positive rate was 70.0 percent.Free HBV DNA was detected in 7 cases of abnormal liver function group.The positive rate was 70.0 percent.The average of free HBV DNA load was no statistical difference between normal liver function group and abnormal liver function group(P0.05).Conclusion There was free HBV DNA in blood serum of hepatitis b patients whose total HBV DNA load was above or equal to 1.0×105 copies/ml.The free HBV DNA load was positive correlation with the total HBV DNA load.The releasing free HBV DNA was not associated with damaged hepatocyte." @default.
- W2388687492 created "2016-06-24" @default.
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- W2388687492 date "2010-01-01" @default.
- W2388687492 modified "2023-09-24" @default.
- W2388687492 title "Study on free Hepatitis B virus DNA in blood serum" @default.
- W2388687492 hasPublicationYear "2010" @default.
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