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- W2388708418 abstract "Objective To investigate the protective effect of melatonin on cardiac muscular tissue of SD rats with chronic intermittent hypoxia in the atmospheric pressure.Methods Twenty-four SD rats were randomly divided into three groups,eight rats in each group.The control group was given normal feeding and room air;The rats in experimental group A were treated with intermittent hypoxia in hypoxic cabin to avoid light as well as given melatonin(1 mg/kg);The rats in experimental group B were treated with intermittent hypoxia in hypoxic cabin to avoid light as well as given physiological saline.The rats' body mass(BM),the ratio of right ventricular mass / left ventricular plus septum mass(RVM / LVSM),the ratio of right ventricular mass / body mass(RVM / BM),glutathione peroxidase(GSHPX) activity,superoxide dismutase(SOD) activity and total antioxidant capacity(T-AOC) were compared among three groups.Results RVM / LVSM,RVM / BM in the experimental group B were significantly higher than those in the experimental group A and control group(P 0.05).BM,GSH-PX activity,SOD activity and T-AOC were significantly lower than those in the experimental group A and control group(P 0.05).There was no significant difference in the indices above between control group and experimental group A(P 0.05).Conclusion Melatonin can protect rats' cardiac muscular tissue from the injury of chronic intermittent hypoxia." @default.
- W2388708418 created "2016-06-24" @default.
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- W2388708418 date "2013-01-01" @default.
- W2388708418 modified "2023-09-23" @default.
- W2388708418 title "Effect of Melatonin on GSH-PX,SOD and T-AOC of Chronic Intermittent Hypoxia Rats'Cardiac Muscular Tissue" @default.
- W2388708418 hasPublicationYear "2013" @default.
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