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- W2388720710 abstract "Objective To explore the relevance of oncogenes, telomerase with the clinicopathologic characteristics of non small cell lung cancer. Methods The expressions of p53, nm23 and telomerase were studied in 40 NSCLC cases by SP and PCR TRAP methods. Results The positive rates of p53, nm23 and telomerase were 37.5%, 17.5% and 92.5% respectively. The expressions of p53 in early stage of T and P TNM were significantly higher than that in the middle and advanced stage( P 0.05). No significant correlations could be found between nm23 expression and the histologic type, lymph nodal metastasis and pathologic staging( P 0.05). The expression of telomerase below 60 year old patients was significantly higher than that in the controlled group( P 0.05). The rates of lymph nodal metastasis and middle, advanced pathologic staging below 60 year old patients were higher than that in the controlled group, 69.2% vs 50% and 76.9% vs 57.1% respectively( P 0.05). There were no significant relationship between p53, nm23 genes and telomerase( P 0.05). Conclusions The expression of p53 can be an early diagnostic and screening method of NSCLC. There is no significant correlation between nm23 expression and histologic type, lymph nodal metastasis or pathologic staging. Telomerase activity is significant related with age and may be implicative in the carcinogenesis and metastasis. There is no significant relationship between p53, nm23 and telomerase." @default.
- W2388720710 created "2016-06-24" @default.
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- W2388720710 date "2002-01-01" @default.
- W2388720710 modified "2023-09-28" @default.
- W2388720710 title "An appraisal on the relevance of expressions of p53 gene, nm23 gene and telomerase with the clinicopathology of non-small cell lung cancer" @default.
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