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- W2388738571 abstract "Objective: To explore the relations between the plasma concentrations of atrial natriuretic peptide(ANP),brain natriuretic peptide(BNP)and C type natriuretic peptide(CNP)and the severity of heart failure and the left ventricular function in patients with congestive heart failure(CHF) and the effect of naftopidil on them. Method: Plasma ANP、BNP and CNP concentrations of 47 patients with congestive heart failure (CHF) and 18 healthy subjects (control group, CG) were measured with radioimmunoassay. The CHF patients were then divided into 2 groups randomly. Patients in group 1 received naftopidil in addition to routine therapy ( group NPD, n =23) while patients in group 2 received routine therapy only (group RT, n =24) for 1 month. Result: 1. The plasma ANP and BNP concentrations of patients were higher than those of normal controls ( P 0 05).They also increased in accordance with the severity of heart failure classified by NYHA’s classification and had a significant negative correlation with the left ventricular ejection fraction. 2. Compared with the normal controls, the plasma CNP concentration significantly increased in patients with mild CHF, while no significant change of that was found in patients with moderate and serious CHF. 3. Both of the therapies were effective in decreasing the levels of ANP and BNP ( P 0 05), and the decrease in group NPD was more obvious ( P 0 05). Conclusions: ANP、BNP and CNP could play an important role in the pathophysiological changes of CHF. Naftopidil in addition to the routine therapy can decrease the levels of ANP and BNP more efficiently [" @default.
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- W2388738571 date "2004-01-01" @default.
- W2388738571 modified "2023-09-25" @default.
- W2388738571 title "Changes of Plasma Natriuretic Peptide Concentrations in Patients with Congestive Heart Failure and the Effect of Naftopidil" @default.
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