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- W2388747865 abstract "Objective To explore the efficacy of Rho-kinase inhibitor and relieving stenosis in the treatment of cognitive dysfunction induced by severe carotid artery stenosis.Methods SD rats were used to establish severe carotid artery stenosis model.After 2 weeks,they were randomly divided into four groups:drug treatment group (receiving intraperitoneal injection of fasudil) ,relieing stenosis group,combined treatment group (relieving stenosis plus fasudil treatment) ,control group.Other 6 rats without carotid artery ligation served as sham-operated group.After different interventions for 2 weeks,Morris water maze test was used to observe changes in cognitive function of the rats and the pathomorphology of rat hippocampus was examined to compare the rate of carotid artery stenosis before and after treatment.Results After treatment,compared with control group,the mean escape latency in rats of other 3 groups significantly reduced (P 0.01), combined treatment group was significantly improved compared with simple drug treatment and stenosis relieving groups (P 0.05).Compared with control group,the rate of carotid stenosis in stenosis relieving and combined treatment groups was significantly decreased (P 0.01).The decrease was more significant in combined therapy than in simple drug treatment and stenosis relieving groups (P 0.01).Varying degrees of improvement of pathological changes in hippocampus were observed in 3 treated groups.Conclusion Relieving carotid stenosis and inhibition of Rhokinase can markedly improve cognitive impairment,and the efficacy of the combined treatment is superior to single treatment." @default.
- W2388747865 created "2016-06-24" @default.
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- W2388747865 date "2010-01-01" @default.
- W2388747865 modified "2023-09-23" @default.
- W2388747865 title "Combined treatment of cognitive impairment induced by severe carotid stenosis with Rho kinase inhibitor and relieving stenosis" @default.
- W2388747865 hasPublicationYear "2010" @default.
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