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- W2388764994 abstract "Objective:To analyze the clinical effects,toxicity and side-effects of the combination chemotherapy mainly with pirarubicin(THP) in the patients of multiple myeloma(MM) and non-Hodgkin lymphoma(NHL).Method:103 patients of MM and NHL were retrospectively analyzed.They were divided into three groups,as well as primary,relapsing and consolidating group,respectively.36 MM patients were treated with VTD regimen(pirarubicin combined with vindesine and dexamethason),the total courses were 184.The curative effects were assessed according to the criterion of the european haematol and bone marrow transplantation group.67 NHL patients were treated with CTOP regimen(pirarucincin combined with CTX,vindesine and dexamethason),the total courses were 162.The curative effects were assessed according to universal criterion of solid tumor established by WHO in 1981.The complete response(CR),partial response(PR),minimal response(MR),no change(NC) and progressive disease(PD) rates were observed.The side-effects were assessed with the WHO criterion of toxicity response to anti-cancer drugs,and divided into 0～Ⅳ grade.Results:CR,PR,MR,NC and PD rates of primary MM patients were 32%,44%,12%,8% and 4%,respectively.Total response rate was 88% and efficient rate was 76%.Total response of the relapsing group of MM was 73.9% and efficient rate was 65.2%.The difference between two groups was not significant(P0.01).The efficient rate in the primary NHL group was 80.8%,while 64.3% in the relapsing group.It was greater in the primary group than in the relapsing group,but the difference was not significant(P0.05).Compared with the combination chemotherapy mainly with ADM,Ⅲ and Ⅳ bone marrow suppression decreased.The toxicity on heart and alopecie also decreased.Conclusion:The combination chemotherapy mainly with THP was of more effects,and less side-effects for MM and NHL patients in the primary,replasing and consolidating stage." @default.
- W2388764994 created "2016-06-24" @default.
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- W2388764994 date "2008-01-01" @default.
- W2388764994 modified "2023-09-23" @default.
- W2388764994 title "Clinical analysis of combination chemotherapy mainly with pirarubicin in 103 patients of multiple myeloma and non-hodgkin lymphoma" @default.
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