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- W2388771369 abstract "Purpose:To clarify roles of overexpression of phosphorylated Akt(p-Akt) and loss of phosphatase and tensin homologue deleted on chromosome 10(PTEN) expression in biological behavior of non-small-cell lung cancer(NSCLC). Methods:Immunohistochemical staining was used to determine the expression of p-Akt and PTEN in 20 cases of normal lung tissues and 102 patients with NSCLC.Results:Negative p-Akt expression and positive PTEN expression were found in normal lung tissues, while the positive incidences of p-Akt expresssion and loss of incidences of PTEN expresssion in NSCLC were 41.2% (42/102) and 46.1% (47/102)respectivtly.The overexpression of p-Akt and loss of PTEN expression were correlated to degree of differention of cancer, metastasis(including lymph node), and clinical stages. A significant negative correlation was observed between expression of p-Akt and PTEN(Phi r=-0.425,P0.001).Conclusions:The present study demonstrates overexpression of p-Akt accompanied by the loss of PTEN in clinical specimes of NSCLC. Both p-Akt and PTEN are concerned with invasion and metastasis of NSCLC." @default.
- W2388771369 created "2016-06-24" @default.
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- W2388771369 date "2005-01-01" @default.
- W2388771369 modified "2023-09-26" @default.
- W2388771369 title "Correlation between Akt phosphorylation and loss of PTEN protein expression in non-small-cell lung cancer" @default.
- W2388771369 hasPublicationYear "2005" @default.
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