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- W2388778899 abstract "Nickel sulfate was inje cted int raperitoneally for normal Wistar rats wi th sexual maturation at varied doses of 1.25 mg/kg,2.50 mg/kg and 5.00 mg/kg dai ly for two weeks.Brain homogenate of the rats was prepared.Content of nickel in brain tissues was assessed with atomic a bsorption spectrophotometry,and activity of nitric oxide synthase(NOS)and conten t of nitric oxide(NO)were examined by en zyme assay.Results showed that contents of nickel and NO in the brain tissues in creased and activity of NOS boosted up s ignificantly in the rats exposed to nick el sulfate.All these indicate that exces sive exposure to nickel sulfate,which ca n permeate through the bloodbrain barri er and accumulate in the brain tissues,c an cause oversynthesis of NO and increa se activity of NOS in the brain tissues of the rats so as to damage their centra l nervous system." @default.
- W2388778899 created "2016-06-24" @default.
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- W2388778899 date "2004-01-01" @default.
- W2388778899 modified "2023-09-23" @default.
- W2388778899 title "Effects of nickel sulfate on nit ric oxide and nitric oxide synthase in brain tissues of rats" @default.
- W2388778899 hasPublicationYear "2004" @default.
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