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- W2388781617 abstract "ObjectiveTo study the alternations of EAAs, IAAs contents the distribution properties of Glu,Asp immunoreactivity in the dorsal horn of spinal cord and the relations between the abnormal neuro-behavior and the changes induced by inflammatory reaction of DRG. MethodsFifty-four health rabbits were divided into three groups: sham-operative (n=24); inflammatory injury (n=24) and control group( n=6). The tissue content of excitatory (Glu,Asp), inhibitory (GABA,Tau)and neutral (Ser, Thr) amino acids were determined in the dorsal horn of spinal cord (SDH). The distribution features of Glu and Asp was also studied by immunohistochemical analyse.Results The obviously increase of Glu,Asp,GABA,Tau,Ser and NMDAR1 in the injured side of SDH (P0.05) ConclusionsThe results showed that the increase of EAAs release in SDH induced by inflammatory irritation played an important role in promoting and maintaining hyperalgesia, but increase of IAAs release is mainly related to protective mechanism. The balance of EAAs/IAAs destroyed by inflammatory injury of DRG was a main factor of the hyperexcitotoxicity injury of nociceptive neurons and hyperalgesia development." @default.
- W2388781617 created "2016-06-24" @default.
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- W2388781617 date "2004-01-01" @default.
- W2388781617 modified "2023-09-24" @default.
- W2388781617 title "The experimental study of the EAAs and IAAs contents changes in the dorsal horn of spinal cord induced by DRG injury" @default.
- W2388781617 hasPublicationYear "2004" @default.
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