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- W2388800778 abstract "Objective:To observe the effect of alprostadil on hemorheology in senile diabetic nephropathy.Methods:Sixty-eight cases of senile diabetic nephropathy were divided into two groups,group 1(n=34)and group2(n=34).Both group1 and group 2 were controlled the blood glucose,diabetic diet and hypoglycemic agents.Group 2 received intervenous infusion treatment with alprostadil 10μg in normal saline 100ml every day for 3 weeks.Both groups were determined hemorheology parameters and albumimuria at the beginning of trial and at the end of it.Results:There was no significant difference of the blood viscosity from low shear rate to high shear rate,erythrocyte aggregation index,erythrocyte sedimentation rate,plasma fibrinogen,platelet aggregation rate and albumimuria between two groups(all P0.05)at the beginning of the trial.The blood viscosity at low shear rate,erythrocyte aggregation index,erythrocyte sedimentation rate,plasma fibrinogen,platelet aggregation rate and albumimuria were significantly lower in both groups at the end of trial than at the beginning of the trial(P0.01),and were significantly lower in group 2 than group 1 at the end of trial(P0.05).Conclusion:Alprostadil can reduce erythrocyte,platelet aggregation in patients with diabetic nephropathy.This may be an effective way to treat and prevent diabetic nephropathy in early stage." @default.
- W2388800778 created "2016-06-24" @default.
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- W2388800778 date "2012-01-01" @default.
- W2388800778 modified "2023-09-22" @default.
- W2388800778 title "Effect of alprostadil on hemorheology in senile diabetic nephropathy" @default.
- W2388800778 hasPublicationYear "2012" @default.
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