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- W2388804596 abstract "Objective To study the role of TLR4 in angiotension Ⅱ(AngⅡ)-induced vascular remodeling of hypertensive mice.Methods Eighteen wild C57 mice were divided into control group,AngⅡgroup and TLR4 group(6 in each group).The mice were infused with AngⅡfor 7 days and injected with TLR4 through the tail vein to neutralize antibodies 2 days before AngⅡinfusion and 7 days after AngⅡinfusion.Expressions of ET-1,α-SMA,PCNA,ICAM-1 and CD69 were detected by immunohistpchemistry and flow cytometry,respectively.Results The blood pressure and expression levels of ET-1,ICAM-1 and CD69 were significantly higher whereas the expression level of α-SMA was significantly lower in AngⅡgroup than in control group(P0.05,P0.01).The blood pressure and expression levels of ET-1,PCNA,ICAM-1 and CD69 were significantly lower whereas the expression level of α-SMA was significantly higher in TLR4 group than in AngⅡgroup(P0.05,P0.01).Conclusion TLR4 participates in AngⅡ-induced vascular remodeling of hypertensive mice by mediating inflammatory reactions." @default.
- W2388804596 created "2016-06-24" @default.
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- W2388804596 date "2013-01-01" @default.
- W2388804596 modified "2023-09-25" @default.
- W2388804596 title "Role of TLR4 in angiotensionII-induced vascular remodeling of hypertensive mice" @default.
- W2388804596 hasPublicationYear "2013" @default.
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