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- W2388808393 abstract "Objective To compare the histologic appearance of tissue in the healing of ultrapulsed CO2 laser and scalpel incisions in the skin of rats.To investigate whether the ultrapulsed CO2 laser delays wound healing in oculoplastic surgery in order to provide guidance for its clinical application.Methods An ultrapulsed CO2 laser incision(laser group) and a scalpel incision(control group) were made in the skin to form two parallel incisions on each of seventy-two male SD rats.An intensity of 6.0 watts was used for the laser incision.The rats were randomly numbered.Wounds were harvested on a time schedule of 0,1,2,3,5,7,10,15 and 20 days.Each specimen was prepared for staining with haematoxylin and eosin.Fibroblasts and TGF-β1 from every section were counted and evaluated independently.Results ①The average time for closure of the laser incisions was 12.8 days while the parallel scalpel incisions healed in 9.0 days,which was significantly earlier(P0.01).②Histological analysis showed that the granulation tissue of the laser group grew slowly and the proliferation of the fibrob-lasts was inhibited(after 5 days,P0.05).Trauma stimulated the fibroblasts' secretion of TGF-β1 with phase characteristics.The secretion of TGF-β1 was inhibited with the laser wound showing an abnormal secretion phase,which had a lower TGF-β1 expression in the intermediate wound healing stage(after 5 days,P0.05).Conclusion The ultrapulsed CO2 laser delayed wound healing due to a dosedependent thermal damage to tissue.This led to a proliferation of fibroblasts and the inhibition of growth factor." @default.
- W2388808393 created "2016-06-24" @default.
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- W2388808393 date "2009-01-01" @default.
- W2388808393 modified "2023-09-22" @default.
- W2388808393 title "The study of wound tissue healing in ultrapulsed carbon dioxide laser incisions" @default.
- W2388808393 hasPublicationYear "2009" @default.
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