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- W2388833727 abstract "Objective:To study the frequencies of various allele and genotpye distributions of intercellular adhesion molecule-1(ICAM-1) gene K496E's polymorphism in patients with type 2 diabetic nephropathy(T2DN) in Zhuang populations in the northern regions in Guilin,and analyzed the correlation of the serum levels and genotype of ICAM-1 with T2DN.Methods:The polymorphism of ICAM-1 gene(including polymorphisms of ICAM-1 gene K469E) of 189 patients with T2DN(of which 94 cases were with DN) and the control group(111 cases with diabetis only) were detected by the polymerase chain reaction-restriction fragment length polymorphisms(PCR-RFLP).Meanwhile,their serum levels of ICAM-1 were determined by enzyme-linked immunosorbent assay(ELISA).Results:The serum levels of ICAM-1 in the DN group were significantly higher than those in the control group(P0.01),there was significant difference of the polymorphism of ICAM-1 gene distributed in the two groups(P0.05).The analysis of relative risk of allele frequencies found that the relative risk of E allele carriers suffered from DN was 1.590 times higher than those of the K allele carriers and the serum ICAM-1 levels of the E allele carriers of DN patients was significantly higher than the K allele carriers of DN patients(P0.01).Conclusions:ICAM-1 gene K469E polymorphism is associated with the pathogenesis of DN,and E allele may be a genetic suscepitibility gene of DN suffers among Zhuang populations in the northern regions of Guilin.ICAM-1 E allele carriers may increase risk by enhancing the ICAM-1 expressions in the pathoogenesis of T2DN." @default.
- W2388833727 created "2016-06-24" @default.
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- W2388833727 date "2010-01-01" @default.
- W2388833727 modified "2023-09-26" @default.
- W2388833727 title "The correlation of the ICAM-1 gene and type II diabetic nephropathy in Zhuang populations in the northern regions of Guilin" @default.
- W2388833727 hasPublicationYear "2010" @default.
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