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- W2388856767 abstract "【Objective】The current study aimed to explore the time response and sensitive indicatiors of oxidation stress induced by one-time intraperitoneal injection of diquat by investigating growth performance and serum anti-oxidation and oxidation parameters in order to establish an oxidation stress model for growing pigs.【Method】Eight DLY growing pigs with BW(36.00±2.50) kg were randomly allotted to two groups with 4 replicates per group and one pig per replicate.Pigs in group 1 or 2 were intraperitoneally injected with diquat at a dose of 8 mg.kg-1 BW or saline.The whole trial period was 35 days.Serum was collected on 0,1,2,3,7,14,21,28 and 35 day for determination of superoxides and anti-oxidative enzyme activities.【Result】Compared to group 2,diquat injection reduced growth performance(P0.05) of pigs at early and whole period of the trial,and decreased serum glutathione peroxidase(GSH-Px)(P0.01) and superoxide dismutase(SOD)(P0.01) activity,reduced the capacity of inhibiting production of hydroxy radical(P0.05) and superoxide anion(P0.01),increased malondialdehyde(MDA)(P0.05) contents.Catalase(CAT) activity also tended to reduce but hydrogen peroxide(H2O2) tended to increase on 7,14,21 and 28 day.No obvious difference was observed for all measurements on 35 day.【Conclusion】Oxidation stress resulted from intraperitoneal injection of diquat(8 mg.kg-1) would last for up to 28 days.Serum SOD,GSH-Px,CAT activities and MDA content were sensitive indicators for oxidation stress." @default.
- W2388856767 created "2016-06-24" @default.
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- W2388856767 date "2008-01-01" @default.
- W2388856767 modified "2023-09-26" @default.
- W2388856767 title "Duration and Indicators of Oxidation Stress Induced by Diquat in Growing Pigs" @default.
- W2388856767 hasPublicationYear "2008" @default.
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