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- W2388891826 abstract "The expression of TLR9 mRNA in Lewis ears with experimental allergic neuritis(EAN) was observed in order to get some idea for the treatment of Guillain-Barre syndrome(GBS) and other autoimmune disorders,in which male Lewis rats were immunized with 100 micrograms of component of PNS myelin sheath protein P0 188-199 and complete Freund's adjuvant(CFA) and the clinic signs and pathological changes in the sciatic nerves of rats were observed.Rats immunized and the control rats were sacrificed at 7,16,24 and 33 days after immunization and the histopathological changes occurring in the embedded paraffin sections of sciatic nerves of rats were examined with HE and Weil staining.Meanwhile,the expression levels of TLR9 mRNA in spleens,sciatic nerves,peripheral blood and lymph nodes were detected dynamically by RT-PCR assay.The experimental results showed that the rats with EAN got the peak of clinic score at 16 days post-immunization,while the clinic manifestations ameliorated obviously 33 days after immunization.In addition,the expression of TLR9 mRNA was up-regulated in the whole course of experimentation and it was comparatively higher than that of the control eats with significant difference(P0.05).These results suggest that TLR9 may play an important role in the initial and effecting stages in pathogenesis of experimental allergic neuritis." @default.
- W2388891826 created "2016-06-24" @default.
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- W2388891826 date "2009-01-01" @default.
- W2388891826 modified "2023-09-23" @default.
- W2388891826 title "The expression of TLR9 mRNA in Lewis rats with experimental allergic neuritis" @default.
- W2388891826 hasPublicationYear "2009" @default.
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