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- W2388894001 abstract "Objective:To investigate the expressions of glypican-3(GPC3) mRNA in hepatocellμLar carcinoma(HCC) tissues and to explore their value in the diagnosis of HCC.Methods: NestedRT-PCR(nRT-PCR) technique was used to detect 76 cases of HCC tissues and its peficancerous tissues as well as the 33 cases in control group.Meanwhile,chemiluminescence method was used to detect the MSAFP in 76 patients with HCC and 33 controls.Results: The relative intensities expression of GPC3 mRNA in HCC,paracancerous,volunteers were 68 cases(89.5%),31 cases(40.8%) and 3 cases(9.1%) respectively.Expresssion of GPC3 mRNA in 44 HCC with AFP positive findings is 41(93.2%),meanwhile in 32 HCC with AFP negative findings is 27(84.3%).The combined detection positive ratio for GPC3 and AFP are 93.4%(71/76).With the prompt of pathological features,the expression of GPC3 not only relates to pathologic grade of HCC,but also relates to the progress and transfer of HCC.Conclusion: GPC3 mRNA may be used as a marker for the early diognosis of HCC in clinic.Combined detection of GPC3 and AFP can provide valuable information in the diognosis of the HCC." @default.
- W2388894001 created "2016-06-24" @default.
- W2388894001 creator A5044906845 @default.
- W2388894001 date "2011-01-01" @default.
- W2388894001 modified "2023-09-23" @default.
- W2388894001 title "Detection of the expression of GPC3 mRNA in the tissue of HCC by nestedRT-PCR" @default.
- W2388894001 hasPublicationYear "2011" @default.
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