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- W2388894271 abstract "Objective To explore the change of leukotriene E4(LTE4) levels in serum and urine in acute period of early wheezing in infants after being intervened by leukotriene(LTS) receptor antagonist for 12 h and 72 h and its clinical significance. Methods Serum and urine samples of the patients diagnosed with infant early wheezing within 24-hours hospitalization were collected,and all the patients took the LTS receptor antagonist.There were 38 patients who provided serum samples,and 77 patients who provided urine samples 12 h after medication;there were 10 patients who provided serum samples,and 13 patients who provided urine samples 72 h after medication.The concentration of LTE4 in serum and urine before and after intervention were detected respectively,and the changes of LTE4 levels in serum and urine in infant early wheezing patients after being intervened by LTS receptor antagonist for 12 h and 72 h were observed. Results The LTE4 concentration in serum in infant early wheezing group after intervention for 12 h,median(M) was 90.66 ng·L-1 and interquartile range(Q) was 459.32 ng·L-1.Compared with the LTE4 concentration in serum before intervention(542.37 ng·L-1,788.65 ng·L-1),there was a significant discrepancy between them(Pa0.01).The LTE4 concentration in serum in infant early wheezing group after intervention for 72 h,M was 67.97 ng·L-1 and Q was 167.69 ng·L-1,compared with the LTE4 concentration in serum before intervention(310.53 ng·L-1,630.36 ng·L-1),there was a significant discrepancy between them(Pa0.05).The LTE4 concentration in urine in infant early wheezing group after intervention for 12 h,M was 7.00 ng·L-1 and Q was 12.74 ng·L-1.Compared with the LTE4 concentration in urine before intervention(7.84 ng·L-1,15.40 ng·L-1),there was no statistical discrepancy between them(Pa0.05).The LTE4 concentration in urine in infant early wheezing group after intervention for 72 h,M was 3.92 ng·L-1 and Q was 9.52 ng·L-1.Compared with the LTE4 concentration in urine before intervention(1.96 ng·L-1,5.74 ng·L-1),there was no statistical discrepancy between them(Pa0.05). Conclusions After being intervened by the LTS receptor antagonist for 12 h and 72 h,the LTE4 concentration in serum decreased significantly.It revealed that LTS receptor antagonist can decrease the serum LTE4 concentration in infant early wheezing patients in a short time(≤3 days),It provides the experimental basis for the use of LTS receptor antagonist in acute period of infant early wheezing.After being intervened by the LTS receptor antagonist for 12 h and 72 h,the urinary LTE4 concentration didn′t change significantly.It revealed that application of LTS receptor antagonist for a short time(≤3 days) didn′t significantly influence the urinary LTE4." @default.
- W2388894271 created "2016-06-24" @default.
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- W2388894271 date "2012-01-01" @default.
- W2388894271 modified "2023-09-24" @default.
- W2388894271 title "Change of Leukotriene E4 Levels in Serum and Urine of Infants with Early Wheezing before and after Intervention and Its Clinical Significance" @default.
- W2388894271 hasPublicationYear "2012" @default.
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