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- W2388897778 abstract "Objective:To evaluate the curative effect and safety of quadruple and sequential therapies for H.pylori eradication. Methods:A total of 150 H.pylori-positive patients were enrolled in the study and randomly allocated into the following three groups: group A were treated with 10 mg rabeprazole bid,220 mg bismuth pectin bid,500 mg clarithromycin bid,1000 mg amoxicillin bid for 7 days;group B were treated with 10 mg rabeprazole bid,1000 mg amoxicillin bid,for the first 5 days;followed by 10 mg rabeprazole bid, 500 mg clarithromycin bid,400 mg metronidazole bid,for the remaining 5 days;group C were treated with 10 mg rabeprazole bid,500 mg clarithromycin bid,1000 mg amoxicillin bid for 7 days.Helicobacter pylori status was assessed by 14C-urea breath test at baseline at 4 weeks after completion of treatment.Results:The eradication rate was 94%in group A,90%in group B,and 68%in group C.The eradication rate of either group A or B was statistically higher than that of group C(P0.01),and there is no statistical difference between the eradication rate of group A and B(P0.05).The three treatment protocols were generally well tolerated.Conclusion: Quadruple and sequential therapies have achieved significantly higher eradication rates in comparison with standard triple therapies.but there is no significant difference between quadruple and sequential therapies." @default.
- W2388897778 created "2016-06-24" @default.
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- W2388897778 date "2011-01-01" @default.
- W2388897778 modified "2023-09-23" @default.
- W2388897778 title "Comparative Study on Quadruple and Sequential Therapies for H.pylori Eradication" @default.
- W2388897778 hasPublicationYear "2011" @default.
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