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- W2388905918 abstract "Objective To evaluate the HIV integrase inhibitory activity of endophvtic fungi in five species of medicinal Dendrobium. Methods The HIV-1 integrase inhibitory activity was detected with high-throughput ELISA. The samples that displayed more than 100% inhibitory effect for HIV-1 integrase were selected for dose-response experiments and anticancer activity screening. Results Among all the tested samples, 19 samples inhibited the HIV-1 integrase activity by more than 80%. Specially, the samples 5119F, 5297F, 5097F, 5140J and 5211F inhibited the enzyme activity by 117.96%, 113.53%, 108.62%, 103.74% and 109.02% respectively. The IC 50 of the five samples was 0.02024, 0.003125, 0.00862, 0.01007 and 0.01192 mg/ml respectively. Conclusion Endophytic fungi of medicinal Dendrobium are potential and abundant reservoir for the screening of HIV-1 integrase inhibitors and are worthy of further study." @default.
- W2388905918 created "2016-06-24" @default.
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- W2388905918 date "2013-01-01" @default.
- W2388905918 modified "2023-09-26" @default.
- W2388905918 title "HIV-1 integrase inhibitory activity of endophytic fungi from five species of medicinal Dendrobium" @default.
- W2388905918 hasPublicationYear "2013" @default.
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