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- W2388946175 abstract "Objective To investigate the change of antidiuretic hormone(ADH) and its influence in renal function in the acute renal failure(ARF) of newborn.Methods Thirty three newborns with ARF were divided into non oliguria group (23 cases) and oliguria group( 10 cases). Osmolarity of plasma and urine were measured with FM 6 type zero point osmometer. ADH in serum were detected by radioimmunoassay. Serum and urine sodium , creatine , creatine clearance (Ccr), fractional sodium excretion (FENa), renal failure index (RFI), free water clearance (CH 2O) were also detected.Twenty eight newborns with normal renal function as control group.Results The ADH of oliguria , non oliguria and control groups were 18.98±7.65, 14.23±6.61, 6.58±3.46 ng/L respectively and were significantly difference among three groups (P0.05). FENa,RFI,Ccr,CH 2O were significantly difference among three groups (P0.05) and plasma urine osmolarity ratio were not significantly among three groups (P0.05). ADH was positive correlated with RFI, FENa (r=0.36 P=0.005) and was negative correlated with Ccr( r=-0.36 P=0.005).Conclusions The newborn with ARF are accompanied by ADH abnormal secretion , ADH increasing is correlated with glomerular filtrating rate decreasing . The renal tubules response to ADH is blunted in the newborn with ARF." @default.
- W2388946175 created "2016-06-24" @default.
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- W2388946175 date "2003-01-01" @default.
- W2388946175 modified "2023-09-25" @default.
- W2388946175 title "The change of antidiuretic hormone in the acute renal failure of newborn" @default.
- W2388946175 hasPublicationYear "2003" @default.
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