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- W2388954802 abstract "Objectives To explore the effects of dietary intervention and physical activity on cardiac structure, collagen contents and MMP-2 activities of high fat-fed obese rats. Methods Twenty-one days old SD rats were randomly divided into two groups, high fat-fed group and control group. After 8 weeks, the rats in high fat-fed group with body weight of at least 20% more than the mean weight of control group were selected and randomly subdivided into obese con- trol group, obese diet-control group and obese diet-control plus exercise group. All rats were sacrificed in the 16th week. Cardiac structural indexes were determined by ultrasound cardiography. Myocardial collagen content was evaluated by quantitative determination of hydroxyproline. MMP-2 activity was measured by SDS-PAGE zymography. Results In high fat-fed obese rats, there were severe hyperlipidemia and left ventricular mass increase along with elevated collagen content and MMP-2 activity. In diet-control group, the hyperlipidemia and left ventricular mass increase were alleviate. However, there were no obvious changes in the collagen content and MMP-2 activity. In diet-control plus exercise group, the body weight decreased further while the left ventricular mass increased. No changes were observed in the collagen content and MMP-2 activity. Conclusions There were left ventricular mass and myocardial collagen content increase in high fat-fed obese rats, which might be related with the activity of MMP-2. Dietary intervention could slow down the progression of ven- tricular reconstitution. Dietary intervention combined with physical activity might benefit the ventricular remodeling." @default.
- W2388954802 created "2016-06-24" @default.
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- W2388954802 date "2009-01-01" @default.
- W2388954802 modified "2023-09-27" @default.
- W2388954802 title "Effects of dietary and athletic intervention on cardiac interstitial remodeling and MMP-2 activities in high fat-fed obese rats" @default.
- W2388954802 hasPublicationYear "2009" @default.
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