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- W2388961244 abstract "Objective: To investigate the neurological effect of exposure to individual and mixtures of dioctyl phthalate( DOP) and arsenic( As) in mice and to discuss resultant preliminary mechanisms associated with the effects. Methods: DOP( 1 000 mg / kg,i. g.) and As( 10 mg / L,p. o.) were administered individually and as mixtures to 4 groups of mice. After 8 weeks of exposure,the enzyme activity,learning and memory abilities and As content in brain of mice were assessed by commercial kits,Morris water mase test and Vista-MPX Simultaneous ICP-OES. The expression of Bax,Bcl-2 and Caspase-3 were performed by Western blot. Results: Mice demonstrated poorer learning and memory performance in exposure groups compared to control. The As level of brain in exposure groups were significantly increased( P 0. 05).ACh E and SOD activities decreased,however,MDA and NOS showed an increase in exposure groups compared to control. The expression of caspase-3 and Bax were significantly increased but Bcl-2 expression was inhibited in the hippocampus,and Bax / Bcl-2 increased. Conclusion: Both DOP and As can induce neurotoxicity in mice associated with hippocampal apoptosis which caused by oxidative stress. The joint toxicity of DOP and As was complicated. Effect of antagonism,synergistic or without interaction were all observed.The mechanism needs to be further studied." @default.
- W2388961244 created "2016-06-24" @default.
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- W2388961244 date "2015-01-01" @default.
- W2388961244 modified "2023-09-26" @default.
- W2388961244 title "Neurological effects of co-exposure of dioctyl phthalate and arsenic in mice and associated mechanism" @default.
- W2388961244 hasPublicationYear "2015" @default.
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