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- W2388964098 abstract "Objective To evaluate the bioequivalence of domestic and imported midodrine hydrochloride tablets in healthy volunteers.Methods A two-way crossover trial was performed in 24 healthy volunteers. Each volunteer was randomized to receive single 5 mg domestic and im- ported preparations seriatim.Plasma concentration of midodrine and the active metabolite desglymidodrine were measured by HPLC.The pharma- cokinetic parameters were calculated and the bioequivalenc of the two preparations was evaluated by DAS1.0 software.Results The main pharmacokinetic parameters of domestic and imported preparations were as follows,midodrine:AUC_(0-t),were (18.46±6.14),(16.93±4.45)μg·h·L~(-1);AUC_(0-∞) were (21.15±7.95),(18.93±5.14)μg·h·L~(-1);C_(max) were (23.51±9.24),(20.61±7.20)μg±L~(-1);t_(max) were (0.49±0.14),(0.46±0.15) h;and t_(1/2) were (2.14±3.28), (2.09±1.70) h;desglymidodrine:AUC_(0-t),were (59.70±16.91), (54.97±13.16)μg·h·L~(-1),AUC_(0-∞) were (64.60±17.94), (58.76±13.72)μg·h·L~(-1);C_(max) were (12.31±3.22),(11.79±3.54)μg·L~(-1);t_(max) were (1.31±0.69),(1.10±0.56) h;and t_(1/2) were (3.95±0.83),(3.55±1.00) h,re- spectively.The relative bioavailability of midodrine and desglymidodrine of domestic tablets relative to imported tablets were (110.44±25.45) % and (108.24±13.82) %.Conclusion The two priparations of midodrine hydrochloride are bioequivalent." @default.
- W2388964098 created "2016-06-24" @default.
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- W2388964098 date "2008-01-01" @default.
- W2388964098 modified "2023-09-22" @default.
- W2388964098 title "Bioequivalence of domestic and imported midodrine hydrochloride tablet in healthy volunteers" @default.
- W2388964098 hasPublicationYear "2008" @default.
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