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- W2388964462 abstract "Objective:The study aims to investigate the expression of integrin αVβ3 and its relationship in gastric cancers.Methods:The tumoral and normal tissues were collected from 65 cases of gastric cancer patients and 40 controls.The clinical phasing and pathological staging of the patients were recorded,and immunohistochemical analysis was used to detect the expression of integrin αVβ3 and microvessel density(MVD)in gastric cancers.Results:The positive rate of integrin αVβ3 expression was significantly higher in gastric cancer tissues than normal mucosal tissues(72.38% vs 22.86%,χ2=8.35,P=0.032).There was a significant difference in integrin αVβ3 expression or MVD between tumors of infiltrating and expanding growth patterns(χ2=14.97,P=0.002;t=10.150,P=0.001,respectively),cancers in T3～T4 and T1～T2 stages(χ2=15.21,P=0.015;t=5.961,P=0.001,respectively).The positive rate of integrin αVβ3 expression and MVD also showed corelationship with lymph node invasion and metastases.Conclusion:Tumoral expression of integrinαVβ3 was closely related with biological behavior of gastric cancers,suggesting that detection of integrin αVβ3 expression may present a potential tool to evaluate the clinical and pathological staging,lymph node status and metastases." @default.
- W2388964462 created "2016-06-24" @default.
- W2388964462 creator A5051482334 @default.
- W2388964462 date "2007-01-01" @default.
- W2388964462 modified "2023-09-28" @default.
- W2388964462 title "Expression of integrin αVβ3 in gastric cancers and its clinical significance" @default.
- W2388964462 hasPublicationYear "2007" @default.
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