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- W2388967593 abstract "Objective:To observe the adverse effect of sodium valproate on pregnant mice,explore the intervention effect of folic acid on the adverse effect.Methods:60 female mice and 30 male mice were randomly divided into 3 groups(30 mice in each group,female∶ male=2∶ 1): the mice in control group were treated with pouring distilled water(10 ml/kg) into stomach;the mice in experimental group were treated with pouring sodium valproate(200 mg/kg) into stomach;the mice in intervention group were treated with pouring sodium valproate(200 mg/kg) and folic acid(0.07 mg/kg) into stomach.The indexes including pregnancy rate,abortion rate,aberration rate,stillbirth rate,the amount of neonatal mice in each brood and the body weight gain during pregnancy were observed.Results:The pregnancy rate of mice in experimental group was the lowest,followed by control group,the pregnancy rate of mice in intervention group was the highest(P0.05).The abortion rate,aberration rate and stillbirth rate of mice in experimental group were the highest,followed by control group,the abortion rate,aberration rate and stillbirth rate of mice in intervention group were the lowest.The amount of neonatal mice in each brood and the body weight gain during pregnancy of mice in experimental group were the lowest,followed by control group,the amount of neonatal mice in each brood and the body weight gain during pregnancy of mice in intervention group were the highest(P0.05).Conclusion:Sodium valproate can lead to increase of pregnant accident of pregnant mice,and supplement of folic acid can reduce the risk of adverse reactions." @default.
- W2388967593 created "2016-06-24" @default.
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- W2388967593 date "2011-01-01" @default.
- W2388967593 modified "2023-09-25" @default.
- W2388967593 title "Study on the adverse effect of sodium valproate on pregnant mice and the intervention of folic acid" @default.
- W2388967593 hasPublicationYear "2011" @default.
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