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- W2388972994 abstract "Objective To investigate the effect of losartan on rats of insulin resistance. Methods Thirty male SD rats were randomly divided into two groups: control group and model group.Insulin resistance was induced in rats by feeding high fat diet while the control rats were fed with regular pellet diet for 4 weeks.Then the model group rats were randomly divided into two groups: losartan treatment group and patho-control group.The treatment group were treated with the losartan(10mg/kg/d) by gastric gavage.The patho-control and control group were given 0.9% NaCl(2ml/d) by gastric gavage.The treatment by gastric gavage would last 6 weeks.At the ends of 4 weeks and 10 weeks respectively,the indexes of body weight,fasting blood glucose(FBG),free fat acid(FFA),fasting insulin(FINS),insulin sensitivity index(ISI),oral glucose tolerance test(OGTT). Results At the end of 10 weeks,treatment group were significantly lower body weight,FINS and FFA compared with patho-control group,while the ISI was significantly higher than that in the patho-control group.The blood glucose of OGTT at 30 minutes,60 minutes and 120minutes in the treatment group were lower than those in the patho-control group. Conclusions Losartan improves insulin resistance of rats." @default.
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- W2388972994 date "2011-01-01" @default.
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- W2388972994 title "The effect of losartan on insulin resistance in rats" @default.
- W2388972994 hasPublicationYear "2011" @default.
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