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- W2388980142 abstract "Objective To observe the effects of simvastatin on silicosis in rats and the possible mechanism of the therapeutic effects.Methods Silicosis of rats was induced by intratracheal injection of silicon dioxide.Forty rats were randomly divided into 4 groups: normal control group(distilled water,10 mL·kg-1),model group and simvastatin groups(10 mg/kg and 20 mg/kg),with 10 rats in each group.After the rats were treated for 28 days with corresponding intragastric administration,their lung index,ratio of dry weight of whole lung to body weight,lung histomorphology,SOD activities as well as MDA and NO contents were detected to evaluate the effects of simvastatin on silicosis in rats.Results Simvastatin reduced the body weight,lung index,and ratio of dry weight of whole lung to body weight.Simvastatin ameliorated obviously inflammation cell infiltration,congestion and dropsy of alveoli pulmonis,pulmonary interstitial fibrosis,and decreased the grade scores of silicotic nodule.It increased markedly SOD activities,but decreased MDA and NO contents in lung tissues of silicosis rats.Conclusion The therapeutic effect of simvastatin on silicosis in rats is related to the decreased level of free radicals." @default.
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- W2388980142 date "2012-01-01" @default.
- W2388980142 modified "2023-09-24" @default.
- W2388980142 title "Therapeutic effects of simvastatin on silicosis in rats" @default.
- W2388980142 hasPublicationYear "2012" @default.
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