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- W2388984908 abstract "Purpose To study the effect of mcl-1 shRNA mediated by lentivirus on the growth and chemotherapy sensitivity of esophageal cancer cells.Methods In this study,the expression level of mcl-1 mRNA and protein were analysed by real-time PCR and western blot,and the growth inhibition rate was evaluated by MTT method,meanwhile the flow cytometry was performed to detect the apoptosis of cells.Results The results showed that the expression level of mcl-1 was obviously decreased after the infection of recombinant lentivirus lenti-mcl-1-shRNA in EC9706 cells,and the proliferation of cells was inhabited compared with the control-shRNA group(P0.05).Flow cytometry showed that the apoptosis was induced by lenti-mcl-1-shRNA in EC9706 cells.In addition,mcl-1-shRNA could improve the cis-platinum sensitivity of EC9706 cells.Conclusion Lenti-mcl-1-shRNA could silence the mcl-1 gene expression in esophageal cancer cells,which lead to the inhibition of proliferation,promotion of apoptosis and improvement of chemotherapy sensitivity in esophageal cancer cells." @default.
- W2388984908 created "2016-06-24" @default.
- W2388984908 creator A5056422120 @default.
- W2388984908 date "2013-01-01" @default.
- W2388984908 modified "2023-09-23" @default.
- W2388984908 title "Effect of shRNA targeting myeloid leukemia-1 gene on the growth and chemotherapy sensitivity of esophageal cancer cells" @default.
- W2388984908 hasPublicationYear "2013" @default.
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