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- W2388991513 abstract "Much less information is known about the role of mannan-binding lectin(MBL) in the regulation of T cell-mediated acquired immune responses mediated by T cells,although it is believed to be of importance in innate immunity.In the present study,T lymphoid cell line Jurkat cells were activated by non-specific stimulatants,such as phytohemagglutinin(PHA),PMA or ionomycin,and the binding of MBL to Jurkat cells was measured by ELISA and FACS.Meanwhile,the impact of MBL on the proliferation of Jurkat cells activation by PHA,PMA or ionomycin and the secretion of IL-2 was analyzed by ELISA and WST-1 assay.It was shown that MBL could significantly bind to PHA/PMA-activated Jurkat cells but slightly bind to the un-activated cells.Also,MBL could significantly inhibit the proliferation of PHA/PMA-activated Jurkat cells at higher concentrations(10~20 mg/L) in a dose-dependent manner,which was not altered by addition of rhIL-2;and that MBL could inhibit IL-2 secretion by PMA/ionomycin-activated Jurkat cells at higher concentrations(10~20 mg/L) in a concentration-dependent manner.All these data suggest that MBL may perform some functions in T cell-mediated acquired immune responses mediated by T cells." @default.
- W2388991513 created "2016-06-24" @default.
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- W2388991513 date "2010-01-01" @default.
- W2388991513 modified "2023-09-23" @default.
- W2388991513 title "Mannan-binding lectin inhibits proliferation of Jurkat cells and secretion of IL-2" @default.
- W2388991513 hasPublicationYear "2010" @default.
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