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- W2388994831 abstract "Objective To explore the influence of ampelopsin( APS) on the expression of cytochrome C oxidase IV( COX-IV) of human retinoblastoma( RB) cell cultured in vitro. Methods Human retinoblastoma RB cell lines( HXO-RB44) cultured in vitro were divided into three groups according the APS concentration,group A( 4. 40 μg / ml),group B( 14. 84 μg / ml) and group C( 33. 33 μg / ml).The blank control group and positive control group( cisplatin,2. 00 μg / ml) were enrolled in the study. The COX-IV expression was determined in each group by Western Blot. Results The COX-IV expression decreased significantly in each APS group after RB cells cultured in vitro had been treated for 24 hours,which showed a significant difference among each APS group,blank control group and positive control group( P 0. 05). The decrease of COX-IV activity expression was the most significant in group A,and the relative grey value was( 0. 112 ± 0. 032). No group presented a characteristic of higher drug concentration and lower COX-IV activity expression. Conclusion APS can reduce the expression of COX-IV. The COX-IV expression may own the threshold,and its expression doesn' t decrease with the increasing APS concentration." @default.
- W2388994831 created "2016-06-24" @default.
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- W2388994831 date "2015-01-01" @default.
- W2388994831 modified "2023-09-23" @default.
- W2388994831 title "Influence of ampelopsin on expression of cytochrome C oxidase of human retinoblastoma HXO-RB44 cells" @default.
- W2388994831 hasPublicationYear "2015" @default.
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