Matches in SemOpenAlex for { <https://semopenalex.org/work/W2388996908> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2388996908 abstract "AIM: To investigate the relationship between the retinal neuroprotective effect of βE2 and the activity of PI3K. METHODS: The relationship between the retinal neuroprotective effect of βE2 and activity of PI3K was investigated by methods of cultured retinal neurons, MTT assay, PI3K assay and Western blot analysis. RESULTS: PI3K activity was increased by a 30 min treatment of cultured retinal neurons with 10 μmol/L βE2 and reached a plateau at 1 h. The PI3K activity returned to control level after 12 h. The incubation of βE2 directly with a homogenate of cultured retinal neurons did not activate PI3K and the expression of PI3K did not respond to βE2 treatment. LY294002, a PI3K inhibitor, greatly inhibited the βE2 attenuated H 2O 2-induced cytotoxicity. CONCLUSION: βE2 can significantly activate PI3K in cells in an indirect way and LY294002 can significantly inhibit the retinal nueroprotection provided by βE2, suggesting that neuroprotective effects of βE2 are related to the activation of PI3K." @default.
- W2388996908 created "2016-06-24" @default.
- W2388996908 creator A5024600483 @default.
- W2388996908 date "2005-01-01" @default.
- W2388996908 modified "2023-09-26" @default.
- W2388996908 title "Relationship between neuroprotective effect of 17β-estradiol and activity of phosphatidylinositol-3-kinase" @default.
- W2388996908 hasPublicationYear "2005" @default.
- W2388996908 type Work @default.
- W2388996908 sameAs 2388996908 @default.
- W2388996908 citedByCount "0" @default.
- W2388996908 crossrefType "journal-article" @default.
- W2388996908 hasAuthorship W2388996908A5024600483 @default.
- W2388996908 hasConcept C109316439 @default.
- W2388996908 hasConcept C184235292 @default.
- W2388996908 hasConcept C185592680 @default.
- W2388996908 hasConcept C190283241 @default.
- W2388996908 hasConcept C202751555 @default.
- W2388996908 hasConcept C25498285 @default.
- W2388996908 hasConcept C25642318 @default.
- W2388996908 hasConcept C2776912716 @default.
- W2388996908 hasConcept C2780610907 @default.
- W2388996908 hasConcept C2780783641 @default.
- W2388996908 hasConcept C2780827179 @default.
- W2388996908 hasConcept C55493867 @default.
- W2388996908 hasConcept C62478195 @default.
- W2388996908 hasConcept C86554907 @default.
- W2388996908 hasConcept C86803240 @default.
- W2388996908 hasConcept C98274493 @default.
- W2388996908 hasConceptScore W2388996908C109316439 @default.
- W2388996908 hasConceptScore W2388996908C184235292 @default.
- W2388996908 hasConceptScore W2388996908C185592680 @default.
- W2388996908 hasConceptScore W2388996908C190283241 @default.
- W2388996908 hasConceptScore W2388996908C202751555 @default.
- W2388996908 hasConceptScore W2388996908C25498285 @default.
- W2388996908 hasConceptScore W2388996908C25642318 @default.
- W2388996908 hasConceptScore W2388996908C2776912716 @default.
- W2388996908 hasConceptScore W2388996908C2780610907 @default.
- W2388996908 hasConceptScore W2388996908C2780783641 @default.
- W2388996908 hasConceptScore W2388996908C2780827179 @default.
- W2388996908 hasConceptScore W2388996908C55493867 @default.
- W2388996908 hasConceptScore W2388996908C62478195 @default.
- W2388996908 hasConceptScore W2388996908C86554907 @default.
- W2388996908 hasConceptScore W2388996908C86803240 @default.
- W2388996908 hasConceptScore W2388996908C98274493 @default.
- W2388996908 hasLocation W23889969081 @default.
- W2388996908 hasOpenAccess W2388996908 @default.
- W2388996908 hasPrimaryLocation W23889969081 @default.
- W2388996908 hasRelatedWork W1533308659 @default.
- W2388996908 hasRelatedWork W1897988540 @default.
- W2388996908 hasRelatedWork W1990520155 @default.
- W2388996908 hasRelatedWork W1993280045 @default.
- W2388996908 hasRelatedWork W2005350078 @default.
- W2388996908 hasRelatedWork W2037096227 @default.
- W2388996908 hasRelatedWork W2043740523 @default.
- W2388996908 hasRelatedWork W2047081898 @default.
- W2388996908 hasRelatedWork W2081110561 @default.
- W2388996908 hasRelatedWork W2352437322 @default.
- W2388996908 hasRelatedWork W2352750792 @default.
- W2388996908 hasRelatedWork W2357217546 @default.
- W2388996908 hasRelatedWork W2357800803 @default.
- W2388996908 hasRelatedWork W2358213367 @default.
- W2388996908 hasRelatedWork W2371355102 @default.
- W2388996908 hasRelatedWork W2373711736 @default.
- W2388996908 hasRelatedWork W2376879189 @default.
- W2388996908 hasRelatedWork W2383372796 @default.
- W2388996908 hasRelatedWork W2390431941 @default.
- W2388996908 hasRelatedWork W900302560 @default.
- W2388996908 isParatext "false" @default.
- W2388996908 isRetracted "false" @default.
- W2388996908 magId "2388996908" @default.
- W2388996908 workType "article" @default.