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- W2388996947 abstract "Objective To investigate the relationship between the expression of p16 and p53 proteins and the clinicopathological feature of buccal cancer.Methods The immunohistochemical stains against p16 and p53 protein was performed to determine expression of oncogene in 30 cases of buccal cancer,32 cases of buccal leukoplakia and buccal lichen planns and 10 cases of normal buccal mucos.All results were analyzed quantitatively by imagine analysis technique. Then,the results were compared with clinico-pathological parameters.Results The positive expression of p16 protein in normal buccal,hyperplasia,atypical hyperplasia,buccal cancer was 100.0%,100.0%,90.0%,and 40.0%,while the positive expression of p53 protein was 0,4.5%,25.0%,53.3%.The positive expression rate of p16 protein in buccal cancer was significantly lower than that in atypical hyperplasia (P＜0.05).The positive expression rate of p53 protein in buccal cancer and atypical hyperplasia were significantly higher than that in hyperplasia (P＜0.05).The expression of P16 in stageⅠandⅡwas significantly higher than that in stageⅢandⅣ(P＜0.01),while expression of P16 in cases without lymph node metastasis was much higher than that in cases with lymph node metastasis (P＜0.05).The expression of P53 in gradeⅠwas significantly lower than that in gradeⅡandⅢ(P＜0.01).Meanwhile, the expression of P53 in stageⅠandⅡwas significantly lower than that in stageⅢandⅣ(P＜0.05),while expression of p53 in cases without lymph node metastasis was much lower than that in cases with lymph node metastasis ( P＜0.05).Conclusion P53 protein could over express in the early stage of buccal cancer.Negative expression of p16 and over expression of P53 in buccal cancer could also predict a poor prognosis.The expressions of p16 and p53 protein could be used as a marker for evaluating clinical stages and metastasis in buccal cancer." @default.
- W2388996947 created "2016-06-24" @default.
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- W2388996947 date "2006-01-01" @default.
- W2388996947 modified "2023-09-26" @default.
- W2388996947 title "Correlation between expression of p53,p16 and clinicopathological feature of buccal cancer" @default.
- W2388996947 hasPublicationYear "2006" @default.
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